Thyroid spindle epithelial tumor with thymus-like differentiation (SETTLE): case report and review Tumor epitelial de células fusiformes com diferenciação thymus-like da tireoide (SETTLE): relato de caso e revisão da literatura
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چکیده
Spindle epithelial tumor with thymus-like element (SETTLE) is a rare malignant neoplasm of the thyroid, occurring predominantly in children, adolescents, and young adults. SETTLE usually presents itself as a thyroid mass, without metastases at diagnosis. It is believed to derive from branchial pouch or thymic remnant tissue showing primitive thymic differentiation. This article reports the clinical, cytological, histological and immunohistochemical features of a SETTLE in a 3-year-old girl. Microscopic exam revealed a nodular, highly cellular neoplasm displayed in the classic biphasic pattern, with mixture of prominent spindle cell component and a minor glandular component lined by mucinous or respiratory-type epithelium. The immunohistochemical study showed strong and diffuse positivity for pan-CK, vimentin and smooth muscle actin. The present case is the first SETTLE case reported in Brazil. To date, the patient described remains without evidence of recurrence or metastasis 5 years after surgery. Arq Bras Endocrinol Metab. 2010;54(7):657-62
منابع مشابه
Spindle Epithelial Tumor with Thymus-Like Differentiation (Settle): A Distinctive Malignant Thyroid Neoplasm: A Case Report
The tumors of intrathyroidal epithelial thymoma are a rare group of thyroid neoplasms.of this , spindle epithelial tumor with thymus like differentiation (SETTLE) has been a rare entity reported only 17 times in English literature. A 34-year-old man had an enlarged thyroid for all of his adult life. Over a period of 12 weeks before hospitalization, the thyroid was noted to enlarge rapidly. Hist...
متن کاملSpindle epithelial tumor with thymus-like differentiation: A case report and comprehensive review of the literature and treatment options.
BACKGROUND Spindle epithelial tumor with thymus-like differentiation (SETTLE) is a rare cancer of thymic origin with little information available for treating clinicians. METHODS We performed a comprehensive literature search and updates were requested from all authors. We report one recent case. RESULTS We present the most comprehensive review of the clinical literature for SETTLE. We iden...
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Thyroid nodules are uncommon in childhood and recurrent thyroid nodules even rarer. Spindle epithelial tumor with thymus-like differentiation (SETTLE), a rare and distinctive low-grade neoplasm is amongst the differential diagnosis of solitary thyroid nodule in children. We describe a boy who underwent completion thyroidectomy for SETTLE in the thyroid remnant four years after initial lobectomy...
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Spindle epithelial tumor with thymus like differentiation (SETTLE) is a very rare tumor arising either from ectopic thymus or remnants of branchial pouches that retain the potential to differentiate along the thymic line.[1]; Herein is reported a case of SETTLE in a 50-year-old man who presented with dessiminated intravascular coagulopathy. The subsequent work up revealed the presence of a medi...
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